Several types of infections of soft tissue may benefit from adjunct treatment with hyperbaric oxygen and are included in the category of “necrotizing soft tissue infections.” Names of such clinical syndromes include crepitant anaerobic cellulitis, progressive bacterial gangrene, necrotizing fasciitis, and nonclostridial myonecrosis. Gas gangrene (clostridial myositis and myonecrosis) is a separate entity.
Hyperbaric Oxygen for Treating Necrotizing Soft Tissue Infections
Necrotizing soft tissue infections themselves may induce conditions adverse to control of the infection by normal host defense mechanisms. Since oxygen is used by white blood cells to kill bacteria, local hypoxia is not uncommon, and contributes to reducing the ability of the white blood cells (neutrophils) to continue to fight infection. Toxins produced by bacteria involved may also inhibit neutrophil activity. The primary treatments for necrotizing soft tissue infection are surgical excision of infected tissue and administration of appropriate antibiotics. Hyperbaric oxygen may be beneficial in several ways. Some of the bacteria involved in necrotizing soft tissue infections are “anaerobic,’ growing most rapidly in a low oxygen environment. In the hyperbaric chamber, tissue oxygen levels may be raised sufficiently to inhibit bacterial growth.